Quantitative Bedside Assay for Cardiac Troponin T: A Complementary Method to Centralized Laboratory Testing
نویسندگان
چکیده
منابع مشابه
Quantitative bedside assay for cardiac troponin T: a complementary method to centralized laboratory testing.
BACKGROUND In the evaluation of chest pain patients, whole blood bedside assays of highly specific cardiac molecules may be an attractive alternative to centralized clinical chemistry testing. We now report on an optimized test strip device for cardiac troponin T (cTnT) that can be analyzed by a cardiac reader for quantitative assessment of the test result. METHODS AND RESULTS The cTnT test s...
متن کاملCardiac troponin T quantitative assay failure as a result of antibody interference
BACKGROUND Immunoassays are prone to interference by various substances which may cause inaccurate results. This type of interference is difficult to detect analytically. OBJECTIVE A case of CARDIAC Troponin T Quantitative reader (Roche Diagnostics) assay failure was detected and investigated in order to ascertain the likely cause. METHOD Patient whole blood was mixed with cardiac troponin ...
متن کاملAnalytical validation of a high-sensitivity cardiac troponin T assay.
BACKGROUND We report the development of a novel high-sensitivity cardiac troponin T (hs-cTnT) assay, a modification of the Roche fourth-generation cTnT assay, and validation of the analytical performance of this assay. METHODS Validation included testing of analytical sensitivity, specificity, interferences, and precision. We established the 99th percentile cutoff from healthy reference popul...
متن کاملTime to positivity of a rapid bedside assay for cardiac-specific troponin T predicts prognosis in acute coronary syndromes: a Thrombolysis in Myocardial Infarction (TIMI) 11A substudy.
OBJECTIVES We sought to determine whether the rapid bedside assay for troponin T identified patients at risk for a more complicated hospital stay and a higher rate of adverse clinical events. BACKGROUND In patients with an acute coronary syndrome, the amount of cardiac-specific troponin T released bears a stoichiometric relation to the extent of myocardial damage. METHODS In 597 patients wi...
متن کاملClinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware.
Roche Diagnostics recently issued a technical bulletin calling for an adjustment to the calibration curve for the Elecsys Troponin T hs and Elecsys Troponin T hs STAT assays. Although this bulletin was disseminated widely in some countries, it was less widely distributed in others. The Roche highsensitivity (hs) assays are in clinical use worldwide except within the US, where they are used for ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1999
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/45.7.1002